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Cutaneous melanoma


Cutaneous melanoma, previously referred to as cutaneous malignant melanoma, is a malignant tumour of cutaneous melanocytes.

In Scotland it is the fifth most common cancer in women and sixth in men. Over the last decade the incidence of melanoma has increased by 38% in men and 22% in women in Scotland, with the most recent incident rate of 26 male and 21.3 female cases per 100,000 in 2013. However, mortality rates in men have been falling, and for women rising at a lower rate than incidence.

The most recent mortality rates are 4 men and 3.3 women per 100,000 in 2013. The primary risk factor for cutaneous melanoma is considered to be exposure to natural and artificial sunlight.

Although melanoma is the major cause of skin cancer mortality it is often curable by surgery, if recognised and treated at an early stage. In recent years considerable efforts have been made to encourage increased public and professional awareness of melanoma in order to promote early detection. In contrast, prognosis for patients with advanced melanoma remains poor although considerable progress has been made with the emergence of molecular therapies (including BRAF inhibitors) and novel immunotherapies which can lead to durable disease control in some patients.

How this guideline was developed

This guideline was developed using a standard methodology based on a systematic review of the evidence. Further details can be found in SIGN 50: A Guideline Developer’s Handbook .

Keeping up to date

This guideline was issued in 2016 and will be considered for review in three years. The review history, and any updates to the guideline in the interim period, will be noted in the review report.

If you are aware of any new evidence that would update this guideline please complete a change request form  and return to:

Current < 3 years


Full guideline (PDF)

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Supporting material

Declarations of interest (PDF)

Search narrative (PDF)

Review report (PDF)

Copyright permission (PDF)

Contact us

SIGN 146 January 2017
ISBN 978 1 905813 49 8

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