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SIGN 104 Antibiotic prophylaxis in surgery

The goal of antibiotic prophylactic in surgical patients is to reduce the incidence of surgical site infection. Antibiotic prophylaxis is one component of an effective policy for the control of healthcare associated infection and is an adjunct to good surgical technique.

SIGN 104 provides information on risk factors for surgical site infection, the benefits and risks of antibiotic prophylaxis, indications for surgical antibiotic prophylaxis and the administration of prophylactic antibiotics (type, timing, dosage, duration and route).

The 2014 update to SIGN 104 provides updated information on:

Clostridium difficile infection (CDI) is an important healthcare associated infection in healthcare settings in Scotland and new evidence of the impact of certain types of antibiotics on CDI rates is presented along with a new recommendation.

The timing of administration of prophylactic antibiotics is important as prophylaxis administered too late or too early reduces the efficacy of the antibiotic and may increase the risk of surgical site infection.  New evidence and a revised recommendation are presented along with a new section on timing of antibiotic prophylaxis in Caesarean section.

The surgery specific quick reference guides have also been updated to reflect the new recommendations.