Guideline 63 - Supporting Material

	Guideline topic: Pharmacological management of asthma Evidence table 4.3g: Oral B2 agonists for exercise induced asthma
Author		Year	Study type	Quality rating	Population	Outomes measured	Effect size	Confidence intervals / p values	Comments
Adults
Gong¹		1990	Randomised, double-blind, placebo-controlled, cross-over. Single dosing with cetirizine 5mg, 10mg and 20mg, and salbutamol 4mg.	++	10 adults with asthma	Exercise-induced bronchoconstriction % fall in FEV1	Placebo: 42% Cetirizine 5mg: 42% Cetirizine 10mg: 44% Cetirizine 20mg: 43% Salbutamol 4mg: 32%	NS NS NS NS NS	Both oral cetrizine and salbutamol had no effect on EIA.
Young people
Sly²		1982	Randomised, double-blind, placebo-controlled, cross-over. Single-dosing with placebo or terbutaline 2.5mg.	++	18 children age 12-18 with asthma	Exercise-induced bronchoconstriction % fall in FEV1	Placebo: 38% Terbutaline: 11%	p<0.05	Oral terbutaline had a significant protective effect against EIA. Part of this effect may be due to an increas in base FEV1 prior to exercise.

Gong H, Jr., Tashkin DP, Dauphinee B, Djahed B, Wu TC. Effects of oral cetirizine, a selective H1 antagonist, on allergen- and exercise-induced bronchoconstriction in subjects with asthma. J Allergy Clin Immunol 1990;85(3):632-41.
Sly RM, O'Brien SR. Effect of oral terbutaline on exercise-induced asthma. Ann Allergy 1982;48(3):151-5.