Author

Magnussen

1988

Randomised, double-blind, placebo-controlled, cross-over.

IV aminophylline 200-351mg vs placebo.

++

11 adults with asthma, aged 16-33 years

Exercise-induced bronchoconstriction

Protection index:

(for the different preparations of aminophylline)

TE 200: 0.61

TE 351: 0.82

TPD: 0.65

p< 0.01

p< 0.01

p< 0.01

A bolus of IV aminophyline significantly attenuated against EIA. Caution needed to extrapolate to oral dosing.

Phillips

1981

Randomised, double-blind, placebo controlled, cross-over.

1 week treatment with oral aminophyline or placebo

++

9 adults with asthma, aged 18-35 years

Exercise-induced bronchoconstriction

4h % fall in PEF

8h % fall in PEF

Placebo vs aminophylline:

30% vs 13%

29% vs 10%

p< 0.01

p< 0.05

Oral aminophylline for 1 week significantly attenuated EIA compared to placebo.