Guideline 63 - Supporting Material

	Guideline topic: Pharmacological management of asthma Evidence table 4.11c: Add-on drugs for inhaled steroids: Anticholinergics
Author		Year	Study type	Quality rating	Population	Outomes measured	Effect size	Confidence intervals / p values	Comments
Macaluso¹		1986	RCT	+	Asthma patients on theophylline	FEV1, GC, cough, dyspnoea	NS difference
Mallfi & Turry		1986	RCT	+	? Asthma patients on other drugs?	FEV1, VC global score	??FEV1, VC global score	P<0.001
Philip-Joet²		1990	RCT	+	? asthma patients on other drugs	FEV, VC, PEFR, dyspnoea	NS difference
Rebuck³		1983	RCT	+	17 patients on ICS, of 22 who were on theophylline	FEV, VC, PEFR	Slight AVC FEV1	P<0.05
Salorinne⁴		1988	RCT	+	Asthma patients on ISST theophylline	FEV1, PEFR, symptoms suffered	PEFR 10-20 l/min	P<0.01
Wolstenholme⁵		1989	RCT	+	Asthma patients on DCSG + ICS	FEV1, PEFR, symptomatic	NS difference

Macaluso S, Del Torre L. Efficacy and compliance to prolonged Duovent treatment of bronchospasm. Comparison with salbutamol. Respiration 1986;50(Suppl 2):222-5.
Philip-Joet F, Reynaud-Gaubert M, Jirou-Najou JL, Arnaud A. Comparison of Berodual and salbutamol in asthma: a multicenter evaluation. Respiration 1990;57(6):379-83.
Rebuck AS, Gent M, Chapman KR. Anticholinergic and sympathomimetic combination therapy of asthma. J Allergy Clin Immunol 1983;71(3):317-23.
Salorinne Y, Ahonen A. Comparison of the bronchodilator effect of ipratropium bromide powder and two doses of ipratropium bromide aerosol in the treatment of asthma. Curr Ther Res Clin Exp 1988;43(6):1073-81.
Wolstenholme RJ, Shettar SP. Comparison of a combination of fenoterol with ipratropium bromide (Duovent) and salbutamol in young adults with nocturnal asthma. Respiration 1989;55(3):152-7.