Guideline 63 - Supporting Material

	Guideline topic: Pharmacological management of asthma Evidence table 4.10: Rhinitis
Author		Year	Study type	Quality rating	Population	Outomes measured	Effect size	Confidence intervals / p values	Comments
Corren¹		1992	RCT Parallel	++	Adult Rhinitis	Nasal symptoms better. No difference in PEFR.			No difference in asthma.
Henriksen²		1984	RCT Parallel	++	Children	PEFR – no difference Asthma symptoms – no difference Nasal symptoms – better
Pedersen³		1990	RCT Cross over	+	Adults seasonal asthma	Nasal symptoms Morning/Evening PEFR – claimed better with active but no baseline. Extra terbutaline better with budesonide.			Very limited evidence that intranasal steroid better.
Watson⁴		1993	RCT	++	Age 7 – 17	Rhinitis better No difference in PEFR

Corren J, Adinoff AD, Buchmeier AD, Irvin CG. Nasal beclomethasone prevents the seasonal increase in bronchial responsiveness in patients with allergic rhinitis and asthma. J Allergy Clin Immunol 1992;90(2):250-6.
Henriksen JM, Wenzel A. Effect of an intranasally administered corticosteroid (budesonide) on nasal obstruction, mouth breathing, and asthma. Am Rev Respir Dis 1984;130(6):1014-8.
Pedersen B, Dahl R, Lindqvist N, Mygind N. Nasal inhalation of the glucocorticoid budesonide from a spacer for the treatment of patients with pollen rhinitis and asthma. Allergy 1990;45(6):451-6.
Watson WT, Becker AB, Simons FE. Treatment of allergic rhinitis with intranasal corticosteroids in patients with mild asthma: effect on lower airway responsiveness. J Allergy Clin Immunol 1993;91(1 Pt 1):97-101.