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12.1 Introduction
SIGN is a collaborative network of clinicians, other healthcare professionals and patient organisations, funded by NHS Quality Improvement Scotland. SIGN guidelines are developed by multidisciplinary groups using a standard methodology based on a systematic review of the evidence. Further details about SIGN and the guideline development methodology are contained in SIGN 50: A guideline developer’s handbook, available at www.sign.ac.uk
12.2 The guideline development group
| Dr Nadeem Siddiqui Chairman |
Consultant Gynaecologist and Oncologist, Stobhill Hospital, Glasgow |
| Dr Chris Hardwick Secretary |
Specialist Registrar in Obstetrics and Gynaecology, North Glasgow Hospitals NHS Trust |
| Dr Ian Aitken | General Practitioner, Glasgow |
| Mr Andrew Anderson | National Coordinator, Maggie’s Centres, Western General Hospital, Edinburgh |
| Mr Roger Black | Head, Scottish Cancer Intelligence Unit, Information and Statistics Division (ISD), Common Services Agency, Edinburgh |
| Ms Sandra Bredin | Clinical Nurse Specialist, Stobhill Hospital, Glasgow |
| Mrs Anne Coote | Patient Helpline Coordinator, Argyll and Clyde Health Council, Paisley |
| Mrs Inez Crow | District Nurse, Falkirk |
| Ms Linda Davidson |
Staff Nurse, Crosshouse Hospital, Kilmarnock |
| Dr Heather Deans | Consultant Radiologist, Aberdeen Royal Infirmary |
| Dr Sonia Devereux | General Practitioner, Forfar |
| Mr Craig Eriksen | Consultant Colorectal Surgeon, Perth Royal Infirmary |
| Dr Marie Fallon | Senior Lecturer in Palliative Medicine, Western General Hospital, Edinburgh |
| Dr Hani Gabra | Consultant in Medical Oncology, Western General Hospital, Edinburgh |
| Professor David Hole | Professor of Epidemiology and Biostatistics, West of Scotland Cancer Surveillance Unit, Department of Public Health, University of Glasgow |
| Dr Brian Magowan | Consultant Gynaecologist, Borders General Hospital, Melrose |
| Mrs Jean McAllister | Principal Biochemist, North Glasgow University Hospitals NHS Trust |
| Dr David W M Millan | Consultant in Pathology, Western Infirmary, Glasgow |
| Miss Kath Nattress | Macmillan Clinical Nurse Specialist, Western General Hospital, Edinburgh |
| Dr David Parkin | Consultant Gynaecological Oncologist, Aberdeen Royal Infirmary |
| Mr Mark Parsons | Principal Clinical Pharmacist, Ninewells Hospital, Dundee |
| Dr Denny Phillips | Consultant Gynaecologist, Perth Royal Infirmary |
| Dr Nicholas Reed | Clinical Director, Beatson Oncology Centre, Glasgow |
| Mr Duncan Service | Information Services Officer, SIGN |
| Dr Sally Stearns | Health Economist, Health Economics Research Unit, University of Aberdeen |
| Professor Michael Steele | Professor in Medical Science, University of St Andrews |
| Mrs Diane Stirling | Macmillan Clinical Nurse Specialist, Western General Hospital, Edinburgh |
| Ms Joanne Topalian | Programme Manager, SIGN |
| Dr Sara Twaddle | Health Economist, North Glasgow Hospitals NHS Trust |
The membership of the guideline development group was confirmed following consultation with the member organisations of SIGN. Declarations of interests were made by all members of the guideline development group. Further details are available from the SIGN Executive.
12.3 Systematic literature review
Literature searches were initially conducted in Medline, Embase, Cinahl, Cancerlit, and the Cochrane Library using the year range 1993-2001. The literature search was updated with new material during the course of the guideline development process. Key websites on the Internet were also used, such as the National Guidelines Clearinghouse. These searches were supplemented by the reference lists of relevant papers and group members’ own files. The Medline version of the main search strategies can be found on the SIGN website.
12.4 Consultation and peer review
12.4.1 NATIONAL OPEN MEETING
The national open meeting is the main consultative phase of SIGN guideline development, at which the guideline development group presents their draft recommendations for the first time. The national open meeting for this guideline was held in June 2002 and was attended by representatives of all key specialties relevant to the guideline. The draft guideline was also available on the SIGN website for a limited period at this stage to allow those unable to attend the meeting to contribute to the development of the guideline.
12.4.2 SPECIALIST REVIEW
SIGN is grateful to the following people for commenting on the peer review draft:
| Dr James Beattie | Director of Guideline Development, Royal College of General Practitioners (Scotland) |
| Ms Helen Berrie | District Nurse, Wallace Medical Centre, Falkirk |
| Dr Kirsty Boyd | Consultant in Palliative Care Medicine, The Royal Infirmary of Edinburgh |
| Dr Bernard L Croall | Clinical Senior Lecturer, Department of Clinical Biochemistry, Grampian University Hospitals Trust, Aberdeen |
| Dr Jo Davis | Consultant Gynaecologist and Oncologist, Stobhill Hospital, Glasgow |
| Dr Ian Duncan | Reader in Obstetrics and Gynaecology, Ninewells Hospital, Dundee |
| Professor Ian Jacobs | Professor of Gynaecological Oncology, Director of Cancer Institute, Barts and the London Hospital, London |
| Professor Stan Kaye | Consultant Oncologist, Royal Marsden Hospital, London |
| Professor Sean Kehoe | Professor of Gynaecological Cancer, Nuffield Department of Obstetrics and Gynaecology, Oxford |
| Dr Harpreet Kohli | Medical Director, Health Technology Assessment, NHS Quality Improvement Scotland |
| Ms Ruth Payne | Administrator, Ovacome, London |
| Dr Claud Regnard | Consultant in Palliative Medicine, St Oswald’s Hospice, Newcastle upon Tyne |
| Dr Terry Rollason | Consultant Histopathologist, Birmingham Women’s Hospital |
| Professor John Smyth | Consultant Medical Oncologist, Western General Hospital, Edinburgh |
| Dr Allan Stevenson | Consultant Radiologist, Western General Hospital, Edinburgh |
| Dr Paul Symonds | Reader in Clinical Oncology, Leicester Royal Infirmary |
Four general practitioners were also invited to review the draft guideline but did not submit any comments.
12.5 Editorial group
As a final quality control check, the guideline is reviewed by an Editorial Group comprising the relevant specialty representatives on SIGN Council to ensure that the peer reviewers’ comments have been addressed adequately and that any risk of bias in the guideline development process as a whole has been minimised. The Editorial Group for this guideline was as follows:
| Mr Douglas Harper | Royal College of Surgeons |
| Dr Grahame Howard | Royal College of Radiologists, Faculty of Oncology |
| Professor Gordon Lowe | Chairman of SIGN, Co-editor |
| Ms Fiona McMillan | Lead Pharmacist, North Glasgow NHS Trust |
| Dr Gillian Penney | Royal College of Obstetrics and Gynaecology |
| Dr Safia Qureshi | Programme Director, SIGN, Co-editor |
| Dr Bernice West | School of Nursing and Midwifery, Faculty of Health and Social Care, The Robert Gordon University, Aberdeen |
| Web contact: duncan.service@nhs.net Last modified 8/12/04 © SIGN 2001-2005 |