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12.1 Introduction
SIGN is a collaborative network of clinicians, other healthcare professionals, and patient organisations, funded by NHS Quality Improvement Scotland. SIGN guidelines are developed by multidisciplinary groups using a standard methodology based on a systematic review of the evidence. Further details about SIGN and the guideline development methodology are contained in “SIGN 50: A Guideline Developer’s Handbook”, available at www.sign.ac.uk
12.2 The guideline development group
| Dr Valerie Doherty (Chairman) | Consultant Dermatologist, Royal Infirmary, Edinburgh |
| Mr Taimur Shoaib (Secretary) | Specialist Registrar in Plastic Surgery, Canniesburn Hospital, Glasgow |
| Ms Moira Black | Health Visitor, Perth |
| Dr David Brewster | Director of Cancer Registration in Scotland, Information and Statistics Division, Edinburgh |
| Dr Graham Duncan | General Practitioner, Kirkcaldy |
| Dr Alan T Evans | Consultant Histopathologist,Ninewells Hospital, Dundee |
| Dr Marie Fallon | Senior Lecturer in Palliative Medicine, Western General Hospital, Edinburgh |
| Mrs Carol Horne | Manager, TakTent Cancer Support, Glasgow |
| Professor Rona MacKie | Consultant Dermatologist, Glasgow University |
| Mrs Lesley Marley | Senior Health Promotion Officer, NHS Tayside, Dundee |
| Mr Alan J McKay | Consultant Vascular Surgeon, Gartnavel General Hospital, Glasgow |
| Dr Kathryn McLaren | Senior Lecturer, Pathology, University of Edinburgh |
| Dr Iain McLellan | General Practitioner, Kilmalcolm, Renfrewshire |
| Dr Nigel McMillan | Consultant Radiologist, Western Infirmary, Glasgow |
| Mr Jack Miller | Consultant Surgeon, Dr Gray’s Hospital, Elgin |
| Dr Marianne Nicolson | Consultant in Medical Oncology, Aberdeen Royal Infirmary |
| Dr Jonathan Norris | Consultant Dermatologist, Dumfries and Galloway Royal Infirmary |
| Dr Gerry Robertson | Consultant Clinical Oncologist, Beatson Oncology Centre, Glasgow |
| Mr Duncan Service | Information Services Officer, SIGN |
| Mrs Karen Smith | Specialist Nurse, Plastic Surgery, Ninewells Hospital,Dundee |
| Mr David Soutar | Consultant Plastic Surgeon, Canniesburn Hospital, Glasgow |
| Ms Joanne Topalian | Programme Manager, SIGN |
The membership of the guideline development group was confirmed following consultation with the member organisations of SIGN. Declarations of interests were made by all members of the guideline development group. Further details are available from the SIGN Executive.
The development group is also very thankful to the following people for their contributions to the development of this guideline:
| Dr Douglas Adamson | Consultant Clinical Oncologist, Ninewells Hospital, Dundee |
| Ms Ailsa Brown | Health Economist, Greater Glasgow Health Board |
12.3 Systematic literature review
Literature searches were initially conducted in Medline, Embase, Cinahl, Cancerlit, and the Cochrane Library using the year range 1993-2001. The literature search was updated with new material during the course of the guideline development process. A final update literature search was performed in March 2003. Key websites on the Internet were also used, such as the National Guidelines Clearinghouse. The searches were extended back to 1970 in areas where evidence was scarce. These searches were supplemented by the reference lists of relevant papers and group members’ own files. The Medline version of the main search strategies can be found on the SIGN website.
12.4 Consultation and peer review
12.4.1 NATIONAL OPEN MEETING
The national open meeting is the main consultative phase of SIGN guideline development, at which the guideline development group presents its draft recommendations for the first time. The national open meeting for this guideline was held in March 2002 and was attended by all of the key specialties relevant to the guideline. The draft guideline was available on the SIGN website for a limited period at this stage to allow those unable to attend the meeting to contribute to the development of the guideline.
12.4.2 SPECIALIST REVIEW
The guideline was also reviewed in draft form by a panel of independent expert referees, who were asked to comment primarily on the comprehensiveness and accuracy of interpretation of the evidence base supporting the recommendations in the guideline. SIGN is very grateful to all of these experts for their contribution to this guideline.
| Dr Alan Begg | General Practitioner, Montrose |
| Dr Frederick Benton | Medical Director, St Columba’s Hospice, Edinburgh |
| Ms Elizabeth Boon | Lay reviewer, Annan, Dumfriesshire |
| Professor Martin Cook | Consultant Pathologist, Royal Surrey County Hospital, Guildford |
| Dr Michael Cornbleet | Senior Medical Officer, Scottish Executive |
| Mr Neil Cox | Consultant Dermatologist, Cumberland Infirmary, Carlisle |
| Ms Ashley Duff | Lay reviewer, Edinburgh |
| Dr Tim Eisen | Consultant Medical Oncologist, The Royal Marsden Hospital, London |
| Dr Jeffrey Evans | Consultant Oncologist, Beatson Oncology Centre, Glasgow |
| Professor Martin Gore | Consultant Medical Oncologist, The Royal Marsden Hospital, London |
| Dr Dermot Gorman | Consultant in Public Health, Lothian NHS Board |
| Dr Robert Grant | General Practitioner, Markinch Medical Practice, Fife |
| Dr Iain Henderson | General Practitioner, Kingsway Medical Practice, Glasgow |
| Dr Richard Johnson | Consultant Radiologist, Christie Hospital, Manchester |
| Dr Hassan Kamel | Consultant Pathologist, Medical School, Edinburgh |
| Mr Peter Lapsley | Chief Executive, Skin Care Campaign, London |
| Professor Hugh MacDougall | Consultant Clinical Oncologist, Western General Hospital, Edinburgh |
| Dr Graham McKillop | Consultant Radiologist, Royal Infirmary, Edinburgh |
| Dr Allan Merry | General Practitioner, Ardrossan |
| Dr Wolter Mooi | Consultant Pathologist, Amsterdam |
| Dr Julia Newton Bishop | Dermatologist, St James’s University Hospital, Leeds |
| Dr Pawlam Patel | Consultant Medical Oncologist, St James’s University Hospital, Leeds |
| Professor Bruce Ponder | Consultant Oncologist, Addenbrooke’s Hospital, Cambridge |
| Professor Roy Rampling | Consultant Oncologist, Beatson Oncology Centre, Glasgow |
| Dr Robin Russell Jones | Consultant Dermatologist, St Thomas’s Hospital, London |
| Ms Jeanette Semple | BACP Accredited Counsellor, Glasgow |
| Professor Anthony Swerdlow | Professor of Epidemiology, The Institute for Cancer Research, London |
| Mr Meirion Thomas | Consultant Surgeon, The Royal Marsden Hospital, London |
| Ms Margaret Thomson | Senior Occupational Therapist, Scottish Occupational Therapy Network in Oncology and Palliative Care, North Glasgow Hospitals Trust |
| Professor John Thompson | Director, The Sydney Melanoma Unit, Professor of Surgery (Melanoma and Surgical Oncology), The University of Sydney, Australia |
| Ms Jennifer Whelan | Head of CancerBACUP Scotland, Glasgow |
12.4.3 SIGN EDITORIAL GROUP
As a final quality control check, the guideline is reviewed by an Editorial Group comprising the relevant specialty representatives on SIGN Council to ensure that the specialist reviewers’ comments have been addressed adequately and that any risk of bias in the guideline development process as a whole has been minimised. The Editorial Group for this guideline was as follows:
| Professor Peter Donnelly | Academy of Medicine |
| Mr Douglas Harper | Royal College of Surgeons, Edinburgh |
| Dr Grahame Howard | Royal College of Radiologists, Faculty of Oncology |
| Professor Gordon Lowe | Chairman of SIGN, Co-editor |
| Dr Safia Qureshi | SIGN Programme Director |
| Dr Sara Twaddle | Director of SIGN, Co-editor |
| Dr Peter Wimpenny | School of Nursing and Midwifery |
Each member of the guideline development group then approved the final guideline for publication.
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contact: duncan.service@nhs.net Last modified 30/11/04 © SIGN 2001-2005 |