Drug

Dose

no. in study

median disease duration

median duration of study

proportion achiveing response

ACR 20⁺

ACR 50⁺

Sulphasalazine¹³⁰

Sulphasalazine⁸⁵

2-3g/day

2g/day

68

133

1 year

7 year

1 year

0.5 year

59%

44%

[34%]*

30%

Methotrexate¹³⁰

Methotrexate⁹⁶

Methotrexate¹³⁹

7.5-15mg/week

7.5-15mg/week

7.5-20mg/week

69

182

217

1.5 years

6 years

1 years

1 year

1 year

1 year

59%

35%

65%

[38%]*

23%

42%

Leflunomide⁸⁵

Leflunomide⁹⁶

20mg/day

20mg/day

133

182

8 years

7 years

0.5 year

1 year

48%

41%

33%

34%

Etanercept¹³⁹

Etanercept¹³⁹

10mg twice weekly (subcutaneous)

25mg twice weekly (subcutaneous)

208

207

1 year

1 year

1 year

1 year

64%

72%

32%

48%