Antibiotic prophylaxis in surgery


Download the guideline

[arrow] Full guideline [Acrobat logo] (785K)
[arrow] Quick reference guide [Acrobat logo] (192K)
arrow Apple app apple badge small
arrow Android app android badge small
arrow Surgery Specific Quick Reference Guides updated in April 2014 to reflect new recommendations relating to timing of antibiotic prophylaxis and the risks of Clostridium difficile infection. These guides can be annotated for use as local implementation tools


SIGN 104 provides information on risk factors for surgical site infection, the benefits and risks of antibiotic prophylaxis, indications for surgical antibiotic prophylaxis and the administration of prophylactic antibiotics (type, timing, dosage, duration and route). The 2014 update provides updated information on the risks of:
Clostridium difficile infection associated with antibiotic prophylaxis (section 4.2.4) and
The timing of administration of antibiotic prophylaxis (section 6.2)

Guideline No. 104, ISBN 978 1 905813 34 6
July 2008, Updated April 2014

Patient information

Supporting material

[arrow] Search narrative [Acrobat logo] (47K)
[arrow] Translation of evidence levels [Acrobat logo] (45K)
[arrow] Register of Interests [Acrobat logo] (22K)
[arrow] Equality Impact Assessment [Acrobat logo] (32K)
[arrow] Calculation of OR and NNT [Acrobat logo] (148K)
[arrow] Copyright Request form [Acrobat logo] (145K)

SIGN Guideline Survey

[Acrobat logo] (139K)


[arrow] Health Protection Network guidance on the control of Clostridium difficile infection in care settings in Scotland [Acrobat logo] (1.12M)
[arrow] Scottish Antimicrobial Prescribing Group (SAPG) guidance on surgical prophylaxis

Related guidelines

Share with a colleague